Southampton took on Cardiff City at St Mary’s on Saturday afternoon in the Bluebirds’ first fixture since Sala’s body was formally identified from the plane wreckage at the bottom of the English Channel.
Sala and pilot David Ibbotson disappeared when flying from Nantes to Cardiff following the striker’s £15million transfer.
Two Saints fans were captured on video making ‘aeroplane gestures’ towards the visiting supporters on Saturday afternoon.
Stewards quickly ejected the pair and they were handed over to the police.
Southampton have since released a statement insisting they will take the necessary action against the duo.
“Southampton Football Club can confirm that two fans were detained and had their details taken by police during our match against Cardiff City on Saturday,” it read.
“The Club will continue to work with Hampshire Police to identify any individuals deemed to have made indecent gestures towards Cardiff supporters.
“Such behaviour has no place in our game and will not be tolerated at St. Mary’s.
“The club will be taking an extremely firm stance against anyone involved and intends to ban those supporters identified.”
Cardiff went on to win the clash 2-1 thanks to a stoppage-time winner Kenneth Zohore.
And manager Neil Warnock credited the victory to Sala.
“You don’t concede in the 93rd and score in the 94th very often, it’s all the highs and lows,” he told Sky Sports.
“Their [Southampton’s] staff were celebrating when they scored, and quite rightly so. I can’t describe it really, it all went quiet for me, I was oblivious to all the noise when the winner went in.
“It was one of those times to have a think and I think we did Emiliano proud today for remembering him and that’s a pleasing thing for me as well.
“We’ve not turned a corner, but we’ve played with a lot more confidence and been a little bit more decisive at the back. In the first half I was disappointed with us on the ball, I thought we could have done more. But in the second half, I thought we played some really good stuff at times.
“People had written us off… and to concede like that but then come back again in injury-time shows tremendous character.”