Federer has won Indian Wells five times before and is looking to go one better after reaching the final last year.
Having started 2018 with a 17-0 record, the 37-year-old was denied back-to-back wins at this tournament for over a decade by Juan Martin del Potro.
The Argentine toppled Federer in a stunning three-set contest, saving three match points for a first ever Masters 1000 title.
Things will be even tougher for Federer this time around, though, with an in-form Novak Djokovic and Rafael Nadal both at Indian Wells this year.
Federer is seeking his 101st career singles title after finally securing his century at the Dubai Tennis Championships last week, beating Greek Stefanos Tsitsipas in the final.
So who could the world No 4 face as he seeks another title?
ROGER FEDERER – PROJECTED INDIAN WELLS DRAW (based on ATP rankings)
First Round – Bye
Second Round – Andreas Seppi
Third Round – Marton Fucsovics
Fourth Round – Fabio Fognini
Quarter Final – Kei Nishikori
Semi Final – Rafael Nadal
Final – Novak Djokovic
Federer is set to kickstart his tournament against Italy’s Seppi, who he has a 14-1 record against – beating him here in 2015, 6-3, 6-4.
After that, the 20-time Grand Slam champion is tipped to be paired against Hungary’s Marton Fucsovics, who he beat in the Dubai quarter-finals last week in straight sets.
Should he navigate those challenges, another Italian – Fabio Fognini – is likely to be his fourth-round opponent.
Fognini is another player who Federer has never lost to having last met at the Paris Masters last November.
From there, three top-10 players are expected to await beginning with Japan’s Kei Nishikori.
The sixth seed beat Federer in the ATP Finals at the end of 2018 to end a six-game losing streak to the Swiss legend.
The semi-finals could pit Federer against long-time rival Nadal in what would be a blockbuster showdown and the 54th meeting of their careers.
And get through that and Federer may have to take on world No 1 Novak Djokovic in the final, with the Serb looking to maintain his excellent form.
Djokovic has won the last three Grand Slams and alongside Federer is the joint-most successful player in Indian Wells history.