Manchester United looked to get back to winning ways after being held by Liverpool last week.
The Red Devils have been in fine form under Ole Gunnar Solskjaer, with the Norwegian yet to lose in the Premier League.
United welcomed Southampton to Old Trafford while Manchester City headed south to take on Bournemouth.
City knew a win would take them back above Liverpool at the top of the Premier League.
There was also a north London derby on today with Arsenal visiting Wembley to take on Tottenham.
But it’s Manchester United’s clash with Southampton that will be first up on Match of the Day tonight (10.20pm).
Then viewers will catch Manchester City’s trip to Bournemouth before the north London derby.
Burnley welcomed Crystal Palace and that will follow with Brighton’s relegation clash with Huddersfield next up.
Cardiff made the trip to Wolves and that will be the penultimate game shown with West Ham and Newcastle doing battle in the final game.
Match of the Day running order
Man Utd vs Southampton
Bournemouth vs Man City
Tottenham vs Arsenal
Burnley vs Crystal Palace
Brighton vs Huddersfield
Wolves vs Cardiff
West Ham vs Newcastle