The four-time MVP missed 17 straight games for the Lakers due to a groin strain sustained on Christmas Day before returning in a 123-120 overtime win over the LA Clippers last week.
LeBron had 24 points, 14 rebounds and nine assists in the Lakers’ win.
But after playing 40 minutes on his return, the 34-year-old opted not to face Golden State with Luke Walton admitting his superstar was “pretty sore” the next day.
The Lakers had done 6-11 in LeBron’s absence and also lost by 14 to the Warriors, a record which sees them down in 10th in the Western Conference.
They can go back to within a game of the Clippers – who occupy eighth spot – with a win against Indiana, but would hold a 27-27 record if they are beaten.
But the good news for the Lakers is that they will have LeBron back in their rotation against the Pacers (4pm PST/midnight UK).
LeBron will not be under a minutes restriction but head coach Walton is keen to ensure he does not over-load the forward and will look to manage him carefully.
He will start the game alongside Brandon Ingram, Rajon Rondo, Kyle Kuzma and Ivica Zubac.
The Lakers leader said: “I’m looking forward to getting back out there with the guys tonight.”
LeBron has averaged 27.2 points, 8.5 rebounds and 7.2 assists per game so far this year.
More to follow.