James has been out since Christmas Day, having suffered a groin injury against the Golden State Warriors.
What followed was the longest period of consecutive missed games in his career.
The superstar has been sorely missed by the Lakers, who have struggled without him.
The team has gone from fourth in the NBA’s Western Conference to ninth, and are now two wins away from the final playoff spot.
The Lakers went 6-11 without James, as they also missed the likes of Kyle Kuzma and Lonzo Ball.
On Wednesday, the Lakers officially ruled James out of contention for a return against the Clippers.
However, earlier on Thursday his status was changed to ‘doubtful’, and it was reported that he would work out before the game and see how he felt.
And after doing work with the medical team, he was declared to be fit to play.
Just over an hour before tip-off against the Clippers, Walton confirmed that he would be back in action.
“He’s gonna give it a go tonight,” he said.
“He came here early and said he felt good.
“Medical staff said he’s good to go, so we’re going to get him out there.
“No minutes limitation, but I’m sure his conditioning won’t be where he wants it to be, so we’ll keep a close eye on him.
“He’s been active in practice, earlier and earlier in the week.
“The last two practices he was a full participant.”
Kuzma, Rajon Rondo and Brandon Ingram will also start.