Manchester United, Arsenal, Liverpool and Chelsea are all primed to splash the cash when the transfer window reopens at the end of the campaign.
And they may be looking at the ongoing crisis at Real Madrid with some eager eyes.
Los Blancos are stuck in a rut and could embark on a mass squad exodus at the end of the campaign. If Jose Mourinho returns, heavyweights such as Sergio Ramos, Isco and Marcelo all may choose to go elsewhere.
So Express Sport looks at how each of the Premier League’s big guns can exploit the current Bernabeu nightmare.
Biggest transfer priority: A centre-back
What could happen? If Manchester United want an experienced head to play alongside Victor Lindelof, then who better than Ramos?
Liverpool fans already hate the Spaniard for crippling Mohamed Salah in last year’s Champions League final.
And Ramos, as a serial winner, would fit the bill. He has won the lot during his time with Los Blancos and came close to moving to Old Trafford in 2015.
If Mourinho returns – and whispers that Florentino Perez wants him back are growing louder – Ramos would likely go. And United, as a club in need of a Lindelof partner, could be the ideal destination.
Biggest transfer priority: A central midfielder
What could happen? Arsenal are going to be operating on a budget this summer, regardless of whether or not they finish in the top four.
They need an experienced head in the middle of the park, though, to help out Lucas Torreira and Matteo Guendouzi.
Therefore, Luka Modric would be a brilliant signing.
His time at Real appears to be winding down and a new manager may want a fresher face. Modric’s Tottenham past may be an issue – but worth a go right?
Biggest transfer priority: A creative midfielder
What could happen? The likeliest player to leave Real Madrid this summer is Isco.
He has had his issues under Santiago Solari but the problems, in long truth, started long before then.
Liverpool still need a creative midfielder following the departure of Philippe Coutinho to Barcelona 14 months ago.
And with Real likely to cut Isco loose, the Spain international may fit the bill.
Biggest transfer priority: An Eden Hazard replacement (if he leaves)
What could happen? Let’s face it, Hazard wants Real Madrid. And, with Gareth Bale struggling, they want him too.
They have already agreed to sign Christian Pulisic but that deal looks independent of whether or not Hazard leaves.
So they’d need an A-lister. And Bale, despite his advancing years and injury record, would be worth a punt.
On his day, he remains a Galactico. And Chelsea fans would love to sign the 29-year-old, especially given his Tottenham past.