The Lakers know what is at stake tonight against the Clippers.
Having fallen to another shock defeat at the weekend, this time against the Phoenix Suns, they are now four-and-a-half games back from a playoff spot.
The Clippers currently occupy seventh, with the San Antonio Spurs close behind them in eighth.
Defeat for the Lakers tonight could all-but end their hopes of reaching the postseason.
And they will have to do so without Ingram, who has been on an impressive scoring run over the past month.
Lakers head coach Luke Walton said Ingram felt some soreness in his shoulder after shoot around today.
They waited to see how Ingram would respond to the game warm-up, but the 21-year-old has now been listed as out for the crunch match.
Ingram joins Lance Stephenson and Tyson Chandler as being unavailable for the Lakers against the Clippers.
It means there will be even more scoring responsibility on LeBron James, who needs 40 points to overtake Michael Jordan in the NBA all-time scoring list.
While the Lakers have only won twice in their six games since the All-Star break, Ingram has certainly stepped up.
He is averaging 27.8 points per game over that period, and his absence will come as a huge blow for the Lakers.